Multiple Sclerosis (MS) is the number one cause of chronic disability among young adults and may affect the student in a multitude of ways. Because MS most often occurs between the ages of 20 and 40, the college student with MS is apt to be in the process of adjusting to the new disability. Depending on the degree to which the MS has progressed, the student's mobility, speech, vision, and emotional state may be affected. One of the most difficult aspects of MS is that the symptoms have a tendency to come and go, but they continue to progress. Periods of remission may last from a few days to months in the early stages. During an exacerbation, the student may appear intoxicated (i.e., slurred speech, staggering, unfocused eyes). Understanding the fluctuations that may occur in the student's behavior make it easier to understand variations in classroom performance. The accommodations, if any, will vary from student to student, depending on the functional limitations.